4TWP
The crystal structure of human abl1 T315I gatekeeper mutant kinase domain in complex with axitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase ABL1 | polymer | 271 | 31417.0 | 2 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (Human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
| 2 | C, H (A, B) | AXITINIB | non-polymer | 386.5 | 2 | Chemie (AXI) | |||
| 3 | D, E, I, J (A, B) | NICKEL (II) ION | non-polymer | 58.7 | 4 | Chemie (NI) | |||
| 4 | F, G, K (A, B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A, B: 233 - 503 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Ile 315 | Thr 315 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62834.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1076.7 | |
| All* | Total formula weight | 63910.8 |
