4S26

Crystal structure of Arabidopsis thaliana ThiC with bound imidazole ribonucleotide, S-adenosylhomocysteine, Fe4S4 cluster and Zn (monoclinic crystal form)

Summary for 4S26

Entry DOI	10.2210/pdb4s26/pdb
Related	3EPM 3EPN 3EPO 4N7Q 4S25 4S27 4S28 4S29 4S2A
Descriptor	Phosphomethylpyrimidine synthase, chloroplastic, IRON/SULFUR CLUSTER, 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole, ... (7 entities in total)
Functional Keywords	alpha-beta barrel, radical sam superfamily, iron-sulfur cluster, thiamin, vitamin b1, vitamin b12, domain swapping, adomet and glutamate mutase, lyase
Biological source	Arabidopsis thaliana (mouse-ear cress,thale-cress)
Cellular location	Plastid, chloroplast stroma : O82392
Total number of polymer chains	2
Total formula weight	131574.35
Authors	Fenwick, M.K.,Mehta, A.P.,Zhang, Y.,Abdelwahed, S.,Begley, T.P.,Ealick, S.E. (deposition date: 2015-01-19, release date: 2015-04-08, Last modification date: 2023-09-20)
Primary citation	Fenwick, M.K.,Mehta, A.P.,Zhang, Y.,Abdelwahed, S.H.,Begley, T.P.,Ealick, S.E. Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase. Nat Commun, 6:6480-6480, Cited by PubMed: 25813242 DOI: 10.1038/ncomms7480 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation