4S1S
Crystal structure of a VRC01-lineage antibody, 45-VRC01.H5.F-185917, in complex with clade A/E HIV-1 gp120 core
Summary for 4S1S
Entry DOI | 10.2210/pdb4s1s/pdb |
Related | 4S1Q 4S1R |
Descriptor | clade A/E 93TH057 HIV-1 gp120 core, Fab of VRC01-lineage antibody,45-VRC01.H5.F-185917 heavy chain, Fab of VRC01 light chain, ... (5 entities in total) |
Functional Keywords | hiv-1, neutralizing antibodies, vrc01-lineage, antibody maturation, evolutionary rate, viral protein-immune system-inhibitor complex, viral protein/immune system/inhibitor |
Biological source | Human immunodeficiency virus 1 (HIV-1) More |
Total number of polymer chains | 3 |
Total formula weight | 89541.44 |
Authors | Kwon, Y.D.,Yang, Y.,Zhang, B.,Kwong, P.D. (deposition date: 2015-01-14, release date: 2015-04-22, Last modification date: 2023-09-20) |
Primary citation | Wu, X.,Zhang, Z.,Schramm, C.A.,Joyce, M.G.,Do Kwon, Y.,Zhou, T.,Sheng, Z.,Zhang, B.,O'Dell, S.,McKee, K.,Georgiev, I.S.,Chuang, G.Y.,Longo, N.S.,Lynch, R.M.,Saunders, K.O.,Soto, C.,Srivatsan, S.,Yang, Y.,Bailer, R.T.,Louder, M.K.,Mullikin, J.C.,Connors, M.,Kwong, P.D.,Mascola, J.R.,Shapiro, L. Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell(Cambridge,Mass.), 161:470-485, 2015 Cited by PubMed: 25865483DOI: 10.1016/j.cell.2015.03.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.39 Å) |
Structure validation
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