4RYZ
Crystal structure of RPE65 in complex with S-emixustat and palmitate
Summary for 4RYZ
Entry DOI | 10.2210/pdb4ryz/pdb |
Related | 3FSN 4RSC 4RYX 4RYY |
Descriptor | Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (5 entities in total) |
Functional Keywords | 7-bladed beta propeller, monotopic membrane protein, non-heme iron enzyme, retinoid isomerase, isomerase |
Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
Cellular location | Cytoplasm: Q28175 |
Total number of polymer chains | 2 |
Total formula weight | 123021.37 |
Authors | Kiser, P.D.,Palczewski, K. (deposition date: 2014-12-17, release date: 2015-05-27, Last modification date: 2021-07-07) |
Primary citation | Zhang, J.,Kiser, P.D.,Badiee, M.,Palczewska, G.,Dong, Z.,Golczak, M.,Tochtrop, G.P.,Palczewski, K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J.Clin.Invest., 125:2781-2794, 2015 Cited by PubMed: 26075817DOI: 10.1172/JCI80950 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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