4RUP

Crystal structure of zVDR L337H mutant-Gemini72 complex

Summary for 4RUP

• Entry DOI: 10.2210/pdb4rup/pdb
• Related: 2HC4 2HCD 4RUJ 4RUO
• Descriptor: Vitamin D3 receptor A, Nuclear receptor coactivator 1, (1R,3R,7E,17beta)-17-[(1R)-6,6,6-trifluoro-5-hydroxy-1-(4-hydroxy-4-methylpentyl)-5-(trifluoromethyl)hex-3-yn-1-yl]-9,1 0-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• Functional Keywords: alpha helical sandwich, transcription factor, retinoid x receptor, ligand, dna, phosphorylation, nucleus
• Biological source: Danio rerio (leopard danio,zebra danio,zebra fish); More
• Total number of polymer chains: 2
• Total formula weight: 36456.40

Authors

Huet, T.,Moras, D.,Rochel, N. (deposition date: 2014-11-21, release date: 2015-10-07, Last modification date: 2024-02-28)

• Primary citation: Huet, T.,Laverny, G.,Ciesielski, F.,Molnar, F.,Ramamoorthy, T.G.,Belorusova, A.Y.,Antony, P.,Potier, N.,Metzger, D.,Moras, D.,Rochel, N.; A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.; Cell Rep, 10:516-526, 2015; PubMed: 25620699; DOI: 10.1016/j.celrep.2014.12.045

Experimental method

X-RAY DIFFRACTION (2.75 Å)