4RUO

Crystal structure of zVDR L337H mutant-gemini complex

Summary for 4RUO

Entry DOI	10.2210/pdb4ruo/pdb
Related	2HC4 2HCD 4RUJ 4RUP
Descriptor	Vitamin D3 receptor A, Nuclear receptor coactivator 2, 21-NOR-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, 20-(4-HYDROXY-4-METHYLPENTYL)-, (1A,3B,5Z,7E), ... (4 entities in total)
Functional Keywords	alpha helical sandwich, transcription factor, retinoid x receptor, ligand, dna, phosphorylation, nucleus, transcription factor-transcription regulator complex, transcription factor/transcription regulator
Biological source	Danio rerio (leopard danio,zebra danio,zebra fish) More
Total number of polymer chains	2
Total formula weight	36168.30
Authors	Huet, T.,Moras, D.,Rochel, N. (deposition date: 2014-11-21, release date: 2015-10-07, Last modification date: 2024-02-28)
Primary citation	Huet, T.,Laverny, G.,Ciesielski, F.,Molnar, F.,Ramamoorthy, T.G.,Belorusova, A.Y.,Antony, P.,Potier, N.,Metzger, D.,Moras, D.,Rochel, N. A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell Rep, 10:516-526, 2015 Cited by PubMed: 25620699 DOI: 10.1016/j.celrep.2014.12.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.805 Å)

Structure validation