4RUJ

Crystal structure of zVDR L337H mutant-VD complex

Summary for 4RUJ

Entry DOI	10.2210/pdb4ruj/pdb
Related	2HC4 2HCD 4RUO 4RUP
Descriptor	Vitamin D3 receptor A, Nuclear receptor coactivator 1, 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ... (4 entities in total)
Functional Keywords	alpha helical sandwich, transcription factor, retinoid x receptor, ligand, dna, phosphorylation, nucleus, transcription factor-transcription regulator complex, transcription factor/transcription regulator
Biological source	Danio rerio (leopard danio,zebra danio,zebra fish) More
Total number of polymer chains	2
Total formula weight	36278.37
Authors	Huet, T.,Moras, D.,Rochel, N. (deposition date: 2014-11-20, release date: 2015-10-07, Last modification date: 2024-02-28)
Primary citation	Huet, T.,Laverny, G.,Ciesielski, F.,Molnar, F.,Ramamoorthy, T.G.,Belorusova, A.Y.,Antony, P.,Potier, N.,Metzger, D.,Moras, D.,Rochel, N. A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell Rep, 10:516-526, 2015 Cited by PubMed: 25620699 DOI: 10.1016/j.celrep.2014.12.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.352 Å)

Structure validation