4RUJ
Crystal structure of zVDR L337H mutant-VD complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D3 receptor A | polymer | 302 | 34085.7 | 1 | UniProt (Q9PTN2) Pfam (PF00104) | Danio rerio (leopard danio zebra danio zebra fish) | VDR-A, 1,25-dihydroxyvitamin D3 receptor A, Nuclear receptor subfamily 1 group I member 1-A |
| 2 | B (B) | Nuclear receptor coactivator 1 | polymer | 15 | 1776.1 | 1 | UniProt (Q15788) | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 3 | C (A) | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL | non-polymer | 416.6 | 1 | Chemie (VDX) PubChem (2524) PubChem (36083) PubChem (134070) PubChem (5283736) PubChem (5283739) PubChem (5283740) PubChem (5283741) PubChem (5283742) PubChem (5353466) PubChem (5371993) PubChem (6376279) PubChem (6434112) PubChem (6437079) PubChem (9802028) PubChem (9823224) PubChem (9866622) PubChem (9909846) PubChem (9963516) PubChem (10093379) PubChem (10180181) PubChem (10180182) PubChem (10873438) PubChem (11112510) PubChem (11292963) PubChem (12096000) PubChem (13019045) PubChem (13019047) PubChem (13019052) PubChem (13019062) PubChem (13019065) PubChem (13019066) PubChem (13019068) PubChem (13019072) PubChem (13019077) PubChem (21158442) PubChem (22811021) PubChem (25056915) PubChem (25144925) PubChem (44348524) PubChem (44445686) PubChem (176541417) PubChem (177626446) PubChem (16759357) PubChem (25244372) PubChem (46780152) PubChem (53846427) PubChem (57358782) PubChem (57824615) PubChem (50990009) PubChem (71434160) PubChem (71776638) PubChem (87065662) PubChem (90690610) PubChem (91507903) PubChem (91884833) PubChem (5280453) PubChem (5283737) PubChem (95566291) PubChem (98043898) PubChem (98043896) PubChem (53675483) PubChem (53846420) PubChem (53846421) PubChem (53846422) PubChem (53846423) PubChem (53846424) PubChem (53846425) PubChem (53846429) PubChem (53846432) PubChem (53846434) PubChem (53846435) PubChem (118719297) PubChem (6439628) PubChem (56675037) PubChem (124554638) PubChem (9844833) PubChem (9953732) PubChem (57069375) PubChem (133655777) PubChem (57853710) PubChem (12096001) PubChem (12095999) PubChem (13019064) PubChem (142186967) PubChem (142965989) PubChem (59072033) PubChem (59824443) PubChem (59966627) PubChem (59966628) PubChem (59966641) PubChem (59966648) PubChem (59966656) PubChem (60120675) PubChem (71296883) PubChem (71586635) PubChem (71699993) PubChem (73707427) PubChem (73946427) PubChem (87060437) PubChem (88093945) PubChem (88093948) PubChem (88205154) PubChem (89082395) PubChem (89187208) PubChem (89735852) PubChem (90909703) PubChem (90942134) PubChem (90997437) PubChem (91170688) PubChem (91172822) PubChem (91400094) PubChem (91442807) PubChem (91543944) PubChem (91884755) PubChem (92974077) PubChem (95566292) PubChem (98043897) PubChem (98043899) PubChem (98116576) PubChem (98621118) PubChem (101088599) PubChem (101099404) PubChem (102426204) PubChem (102552746) PubChem (117828099) PubChem (118855589) PubChem (122451302) PubChem (123249588) PubChem (124220088) PubChem (124584674) PubChem (124604783) PubChem (125032907) PubChem (129010338) PubChem (129627816) PubChem (129631814) PubChem (131954609) PubChem (134693124) PubChem (134694664) PubChem (139024314) PubChem (154790143) PubChem (154831899) PubChem (156599239) PubChem (162489847) PubChem (162904206) PubChem (163285334) PubChem (164576789) PubChem (166640002) PubChem (171114678) PubChem (171157379) PubChem (172966559) PubChem (173519260) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A: 156 - 453 (UniProt: Q9PTN2)
| PDB | External Database | Details |
|---|---|---|
| Gly 152 | - | expression tag |
| Ser 153 | - | expression tag |
| His 154 | - | expression tag |
| Met 155 | - | expression tag |
| His 337 | Leu 337 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35861.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 416.6 | |
| All* | Total formula weight | 36278.4 |
