4RRV

Crystal structure of PDK1 in complex with ATP and PIFtide

Summary for 4RRV

• Entry DOI: 10.2210/pdb4rrv/pdb
• Related: 4RQK 4RQV
• Descriptor: 3-phosphoinositide-dependent protein kinase 1, Serine/threonine-protein kinase N2, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: protein kinase, piftide, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: O15530 Q16513
• Total number of polymer chains: 2
• Total formula weight: 38079.04

Authors

Rettenmaier, T.J.,Wells, J.A. (deposition date: 2014-11-06, release date: 2014-12-17, Last modification date: 2023-09-20)

• Primary citation: Rettenmaier, T.J.,Sadowsky, J.D.,Thomsen, N.D.,Chen, S.C.,Doak, A.K.,Arkin, M.R.,Wells, J.A.; A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.; Proc.Natl.Acad.Sci.USA, 111:18590-18595, 2014; PubMed: 25518860; DOI: 10.1073/pnas.1415365112

Experimental method

X-RAY DIFFRACTION (1.412 Å)