4RQV
Crystal structure of PDK1 in complex with ATP and the PIF-pocket ligand RS2
Summary for 4RQV
| Entry DOI | 10.2210/pdb4rqv/pdb |
| Related | 4RQK 4RRV |
| Descriptor | 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | protein kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: O15530 |
| Total number of polymer chains | 1 |
| Total formula weight | 36649.01 |
| Authors | Rettenmaier, T.J.,Wells, J.A. (deposition date: 2014-11-05, release date: 2014-12-17, Last modification date: 2023-09-20) |
| Primary citation | Rettenmaier, T.J.,Sadowsky, J.D.,Thomsen, N.D.,Chen, S.C.,Doak, A.K.,Arkin, M.R.,Wells, J.A. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc.Natl.Acad.Sci.USA, 111:18590-18595, 2014 Cited by PubMed: 25518860DOI: 10.1073/pnas.1415365112 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.502 Å) |
Structure validation
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