4RPQ

Human Aldose Reductase complexed with a ligand with an IDD structure at 1.20 A (1)

Summary for 4RPQ

• Entry DOI: 10.2210/pdb4rpq/pdb
• Related: 1US0 4PUU 4PUW 4Q7B 4QBX 4QR6
• Descriptor: Aldose reductase, ({3-[(3-nitrobenzyl)carbamoyl]biphenyl-4-yl}oxy)acetic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: tim barrel, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 36916.94

Authors

Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2014-10-31, release date: 2015-11-18, Last modification date: 2023-09-20)

• Primary citation: Rechlin, C.,Scheer, F.,Heine, A.,Diederich, W.,Klebe, G.; Aldose Reductase: IDD ligands under investigation; To be Published,

Experimental method

X-RAY DIFFRACTION (1.2 Å)