4RPL

Crystal structure of Micobacterium tuberculosis UDP-Galactopyranose mutase in complex with tetrafluorinated substrate analog UDP-F4-Galp

Summary for 4RPL

Entry DOI	10.2210/pdb4rpl/pdb
Related	1V0J 4RPG 4RPH 4RPJ 4RPK
Descriptor	UDP-galactopyranose mutase, FLAVIN-ADENINE DINUCLEOTIDE, [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,5S,6R)-3,3,4,4-tetrafluoro-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name), ... (4 entities in total)
Functional Keywords	udp-galactopyranose mutase, mtugm, flavoenzyme, fad, isomerase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	3
Total formula weight	141960.49
Authors	Van Straaten, K.E.,Sanders, D.A.R. (deposition date: 2014-10-30, release date: 2015-01-21, Last modification date: 2023-09-20)
Primary citation	van Straaten, K.E.,Kuttiyatveetil, J.R.,Sevrain, C.M.,Villaume, S.A.,Jimenez-Barbero, J.,Linclau, B.,Vincent, S.P.,Sanders, D.A. Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase from Mycobacterium tuberculosis Using Substrate and Tetrafluorinated Substrate Analogues. J.Am.Chem.Soc., 137:1230-1244, 2015 Cited by PubMed: 25562380 DOI: 10.1021/ja511204p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2499 Å)

Structure validation