4RPL
Crystal structure of Micobacterium tuberculosis UDP-Galactopyranose mutase in complex with tetrafluorinated substrate analog UDP-F4-Galp
Summary for 4RPL
Entry DOI | 10.2210/pdb4rpl/pdb |
Related | 1V0J 4RPG 4RPH 4RPJ 4RPK |
Descriptor | UDP-galactopyranose mutase, FLAVIN-ADENINE DINUCLEOTIDE, [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,5S,6R)-3,3,4,4-tetrafluoro-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name), ... (4 entities in total) |
Functional Keywords | udp-galactopyranose mutase, mtugm, flavoenzyme, fad, isomerase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 3 |
Total formula weight | 141960.49 |
Authors | Van Straaten, K.E.,Sanders, D.A.R. (deposition date: 2014-10-30, release date: 2015-01-21, Last modification date: 2023-09-20) |
Primary citation | van Straaten, K.E.,Kuttiyatveetil, J.R.,Sevrain, C.M.,Villaume, S.A.,Jimenez-Barbero, J.,Linclau, B.,Vincent, S.P.,Sanders, D.A. Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase from Mycobacterium tuberculosis Using Substrate and Tetrafluorinated Substrate Analogues. J.Am.Chem.Soc., 137:1230-1244, 2015 Cited by PubMed: 25562380DOI: 10.1021/ja511204p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2499 Å) |
Structure validation
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