4RPK

Crystal structure of Micobacterium tuberculosis UDP-Galactopyranose mutase in complex with tetrafluorinated substrate analog UDP-F4-Galf

Summary for 4RPK

• Entry DOI: 10.2210/pdb4rpk/pdb
• Related: 1V0J 4RPG 4RPH 4RPJ 4RPL
• Descriptor: UDP-galactopyranose mutase, FLAVIN-ADENINE DINUCLEOTIDE, (2R,5S)-5-[(1R)-1,2-dihydroxyethyl]-3,3,4,4-tetrafluorotetrahydrofuran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name), ... (4 entities in total)
• Functional Keywords: udp-galactopyranose mutase, mtugm, flavoenzyme, fad, isomerase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 3
• Total formula weight: 141960.49

Authors

Van Straaten, K.E.,Sanders, D.A.R. (deposition date: 2014-10-30, release date: 2015-01-21, Last modification date: 2023-09-20)

• Primary citation: van Straaten, K.E.,Kuttiyatveetil, J.R.,Sevrain, C.M.,Villaume, S.A.,Jimenez-Barbero, J.,Linclau, B.,Vincent, S.P.,Sanders, D.A.; Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase from Mycobacterium tuberculosis Using Substrate and Tetrafluorinated Substrate Analogues.; J.Am.Chem.Soc., 137:1230-1244, 2015; PubMed: 25562380; DOI: 10.1021/ja511204p

Experimental method

X-RAY DIFFRACTION (2.55 Å)