4RPL

Crystal structure of Micobacterium tuberculosis UDP-Galactopyranose mutase in complex with tetrafluorinated substrate analog UDP-F4-Galp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008767	molecular_function	UDP-galactopyranose mutase activity
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016853	molecular_function	isomerase activity
A	0045227	biological_process	capsule polysaccharide biosynthetic process
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0071555	biological_process	cell wall organization
A	0071766	biological_process	Actinobacterium-type cell wall biogenesis
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008767	molecular_function	UDP-galactopyranose mutase activity
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016853	molecular_function	isomerase activity
B	0045227	biological_process	capsule polysaccharide biosynthetic process
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0071555	biological_process	cell wall organization
B	0071766	biological_process	Actinobacterium-type cell wall biogenesis
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008767	molecular_function	UDP-galactopyranose mutase activity
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016853	molecular_function	isomerase activity
C	0045227	biological_process	capsule polysaccharide biosynthetic process
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0071555	biological_process	cell wall organization
C	0071766	biological_process	Actinobacterium-type cell wall biogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE FAD B 401

Chain	Residue
B	VAL13
B	GLY45
B	ASN46
B	TYR62
B	ALA64
B	HIS65
B	LEU66
B	ASP224
B	TRP225
B	PHE226
B	THR244
B	GLY14
B	GLY245
B	LEU263
B	TYR327
B	ARG360
B	LEU367
B	ASP368
B	MET369
B	ALA372
B	3UC402
B	HOH508
B	GLY16
B	HOH509
B	HOH510
B	HOH630
B	HOH632
B	PHE17
B	PHE18
B	LEU37
B	GLU38
B	ARG39
B	ARG40

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE 3UC B 402

Chain	Residue
B	ALA64
B	LEU66
B	HIS89
B	VAL91
B	PHE102
B	PHE157
B	VAL158
B	TYR161
B	THR162
B	TRP166
B	ASN177
B	ARG180
B	LEU181
B	TYR191
B	PHE192
B	ASN282
B	ASN284
B	ARG292
B	TYR328
B	TYR366
B	FAD401
B	HOH596
B	HOH638
B	HOH641
B	HOH649

---

site_id	AC3
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD A 401

Chain	Residue
A	VAL13
A	GLY14
A	GLY16
A	PHE17
A	PHE18
A	LEU37
A	GLU38
A	ARG39
A	ARG40
A	GLY45
A	ASN46
A	TYR62
A	ALA64
A	HIS65
A	LEU66
A	ASP224
A	TRP225
A	PHE226
A	GLY245
A	PRO246
A	LEU263
A	TYR327
A	TYR328
A	GLY359
A	ARG360
A	LEU367
A	ASP368
A	MET369
A	ALA372
A	3UC402
A	HOH504
A	HOH508
A	HOH554
A	HOH629

---

site_id	AC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE 3UC A 402

Chain	Residue
A	TYR161
A	THR162
A	TRP166
A	ASN177
A	ILE178
A	ARG180
A	LEU181
A	TYR191
A	PHE192
A	ASN282
A	ASN284
A	ARG292
A	TYR328
A	TYR366
A	FAD401
A	HOH547
A	HOH631
A	HOH634
A	HOH649
A	ALA64
A	LEU66
A	HIS89
A	VAL91
A	PHE102
A	PHE157
A	VAL158

---

site_id	AC5
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD C 401

Chain	Residue
C	GLY14
C	GLY16
C	PHE17
C	PHE18
C	LEU37
C	GLU38
C	ARG39
C	ARG40
C	GLY45
C	ASN46
C	TYR62
C	ALA64
C	HIS65
C	LEU66
C	THR223
C	ASP224
C	TRP225
C	PHE226
C	THR244
C	GLY245
C	LEU263
C	TYR327
C	GLY359
C	ARG360
C	TYR366
C	LEU367
C	ASP368
C	MET369
C	3UC402
C	HOH517
C	HOH518
C	HOH567
C	HOH600
C	HOH608

---

site_id	AC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE 3UC C 402

Chain	Residue
C	ALA64
C	LEU66
C	HIS89
C	VAL91
C	PHE102
C	PHE157
C	TYR161
C	THR162
C	GLN165
C	ASN177
C	ILE178
C	ARG180
C	LEU181
C	TYR191
C	PHE192
C	ASN282
C	ASN284
C	ARG292
C	TYR328
C	TYR366
C	FAD401
C	HOH502
C	HOH604
C	HOH618
C	HOH619

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	BINDING: BINDING => ECO:0000269|PubMed:15843027

Chain	Residue	Details
B	LEU367
A	PHE18
A	GLU38
A	ASN46
A	LEU66
A	ASP224
A	ARG360
A	LEU367
C	PHE18
C	GLU38
C	ASN46
C	LEU66
C	ASP224
C	ARG360
C	LEU367
B	PHE18
B	GLU38
B	ASN46
B	LEU66
B	ASP224
B	ARG360

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	TYR328
B	TYR366
A	PHE157
A	THR162
A	TRP166
A	TYR191
A	ASN282
A	ARG292
A	TYR328
A	TYR366
C	PHE157
C	THR162
C	TRP166
C	TYR191
C	ASN282
C	ARG292
C	TYR328
C	TYR366
B	PHE157
B	THR162
B	TRP166
B	TYR191
B	ASN282
B	ARG292

---