4RMW

Crystal structure of the D76A Beta-2 Microglobulin mutant

Summary for 4RMW

Entry DOI	10.2210/pdb4rmw/pdb
Related	2YXF 4FXL 4RMQ 4RMR 4RMS 4RMT 4RMU 4RMV
Descriptor	Beta-2-microglobulin, TRIETHYLENE GLYCOL, ACETATE ION, ... (4 entities in total)
Functional Keywords	immunoglobin, beta-sandwitch, amyloidosis, pathologic mutation, genetic disease, mhc class i, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	12044.56
Authors	de Rosa, M.,Bolognesi, M.,Ricagno, S. (deposition date: 2014-10-22, release date: 2015-11-18, Last modification date: 2023-09-20)
Primary citation	Le Marchand, T.,de Rosa, M.,Salvi, N.,Sala, B.M.,Andreas, L.B.,Barbet-Massin, E.,Sormanni, P.,Barbiroli, A.,Porcari, R.,Sousa Mota, C.,de Sanctis, D.,Bolognesi, M.,Emsley, L.,Bellotti, V.,Blackledge, M.,Camilloni, C.,Pintacuda, G.,Ricagno, S. Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity. Nat Commun, 9:1658-1658, 2018 Cited by PubMed: 29695721 DOI: 10.1038/s41467-018-04078-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation