4RMJ

Human Sirt2 in complex with ADP ribose and nicotinamide

Summary for 4RMJ

• Entry DOI: 10.2210/pdb4rmj/pdb
• Related: 4RMG 4RMH 4RMI
• Descriptor: NAD-dependent protein deacetylase sirtuin-2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, NICOTINAMIDE, ... (9 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6
• Total number of polymer chains: 2
• Total formula weight: 70670.52

Authors

Rumpf, T.,Schiedel, M.,Karaman, B.,Roessler, C.,North, B.J.,Lehotzky, A.,Olah, J.,Ladwein, K.I.,Schmidtkunz, K.,Gajer, M.,Pannek, M.,Steegborn, C.,Sinclair, D.A.,Gerhardt, S.,Ovadi, J.,Schutkowski, M.,Sippl, W.,Einsle, O.,Jung, M. (deposition date: 2014-10-21, release date: 2015-02-25, Last modification date: 2024-02-28)

• Primary citation: Rumpf, T.,Schiedel, M.,Karaman, B.,Roessler, C.,North, B.J.,Lehotzky, A.,Olah, J.,Ladwein, K.I.,Schmidtkunz, K.,Gajer, M.,Pannek, M.,Steegborn, C.,Sinclair, D.A.,Gerhardt, S.,Ovadi, J.,Schutkowski, M.,Sippl, W.,Einsle, O.,Jung, M.; Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.; Nat Commun, 6:6263-6263, 2015; PubMed: 25672491; DOI: 10.1038/ncomms7263

Experimental method

X-RAY DIFFRACTION (1.87 Å)