4RI8

FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA

Summary for 4RI8

• Entry DOI: 10.2210/pdb4ri8/pdb
• Related: 4RI9 4RIA 4RIB 4RIC 4RID
• Descriptor: Fanconi-associated nuclease 1, DNA (5'-D(*TP*TP*TP*GP*AP*GP*GP*AP*GP*TP*CP*TP*TP*T)-3'), DNA (5'-D(P*GP*AP*GP*GP*CP*GP*TP*G)-3'), ... (5 entities in total)
• Functional Keywords: nuclease, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q9Y2M0
• Total number of polymer chains: 8
• Total formula weight: 173018.58

Authors

Pavletich, N.P.,Wang, R. (deposition date: 2014-10-05, release date: 2014-12-03, Last modification date: 2024-02-28)

• Primary citation: Wang, R.,Persky, N.S.,Yoo, B.,Ouerfelli, O.,Smogorzewska, A.,Elledge, S.J.,Pavletich, N.P.; DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.; Science, 346:1127-1130, 2014; PubMed: 25430771; DOI: 10.1126/science.1258973

Experimental method

X-RAY DIFFRACTION (2.9 Å)