4RI8
FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Fanconi-associated nuclease 1 | polymer | 651 | 73926.0 | 2 | UniProt (Q9Y2M0) Pfam (PF21315) Pfam (PF21169) Pfam (PF21170) Pfam (PF08774) In PDB | Homo sapiens (human) | FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15 |
| 2 | E, H | DNA (5'-D(*TP*TP*TP*GP*AP*GP*GP*AP*GP*TP*CP*TP*TP*T)-3') | polymer | 14 | 4316.8 | 2 | |||
| 3 | F, I | DNA (5'-D(P*GP*AP*GP*GP*CP*GP*TP*G)-3') | polymer | 8 | 2507.7 | 2 | |||
| 4 | G, J | DNA (5'-D(*AP*AP*CP*AP*CP*GP*CP*CP*TP*AP*GP*AP*CP*TP*CP*CP*TP*CP*A)-3') | polymer | 19 | 5718.7 | 2 | |||
| 5 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
A, B: 370 - 1017 (UniProt: Q9Y2M0)
| PDB | External Database | Details |
|---|---|---|
| Gly 358 | - | expression tag |
| Ala 359 | - | expression tag |
| His 360 | - | expression tag |
| Met 361 | - | expression tag |
| Thr 362 | - | expression tag |
| Arg 363 | - | expression tag |
| Asn 364 | - | expression tag |
| Gly 365 | - | expression tag |
| Pro 366 | - | expression tag |
| Gly 367 | - | expression tag |
| Gln 368 | - | expression tag |
| Thr 369 | - | expression tag |
| Ala 487 | Val 487 | engineered mutation |
| - | Cys 510 | deletion |
| - | Thr 511 | deletion |
| - | Trp 512 | deletion |
| - | Gly 513 | deletion |
| - | Lys 514 | deletion |
| - | Asn 515 | deletion |
| - | Lys 516 | deletion |
| - | Pro 517 | deletion |
| - | Gly 518 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 172938.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 80.2 | |
| All* | Total formula weight | 173018.6 |
