4RFE

Crystal structure of ADCC-potent ANTI-HIV-1 Rhesus macaque antibody JR4 Fab

Summary for 4RFE

• Entry DOI: 10.2210/pdb4rfe/pdb
• Related: 4H8W 4JZW 4RFN 4RFO
• Descriptor: Fab heavy chain of ADCC-potent anti-HIV-1 antibody JR4, Fab light chain of ADCC-potent anti-HIV-1 antibody JR4, SULFATE ION, ... (6 entities in total)
• Functional Keywords: hiv-1 gp120 specific antibody, cd4i antibody, adcc, hiv-1 env, anti-hiv-1 env antibody jr4, immune system
• Biological source: Macaca mulatta (rhesus macaque); More
• Total number of polymer chains: 8
• Total formula weight: 190870.91

Authors

Wu, X.,Gohain, N.,Tolbert, W.D.,Pazgier, M. (deposition date: 2014-09-25, release date: 2015-07-15, Last modification date: 2023-09-20)

• Primary citation: Gohain, N.,Tolbert, W.D.,Acharya, P.,Yu, L.,Liu, T.,Zhao, P.,Orlandi, C.,Visciano, M.L.,Kamin-Lewis, R.,Sajadi, M.M.,Martin, L.,Robinson, J.E.,Kwong, P.D.,DeVico, A.L.,Ray, K.,Lewis, G.K.,Pazgier, M.; Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.; J.Virol., 89:8840-8854, 2015; PubMed: 26085162; DOI: 10.1128/JVI.01232-15

Experimental method

X-RAY DIFFRACTION (1.91 Å)