4RA5
Human Protein Kinase C THETA IN COMPLEX WITH LIGAND COMPOUND 11a (6-[(1,3-Dimethyl-azetidin-3-yl)-methyl-amino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one)
Summary for 4RA5
Entry DOI | 10.2210/pdb4ra5/pdb |
Related | 4Q9S 4Q9Z 4RA4 |
Descriptor | HUMAN PROTEIN KINASE C THETA, (1R)-9-[(1,3-dimethylazetidin-3-yl)(methyl)amino]-1-methyl-8-phenyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one, SODIUM ION, ... (5 entities in total) |
Functional Keywords | pkc theta kinase, kinase domain, proteros biostructures gmbh, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q04759 |
Total number of polymer chains | 2 |
Total formula weight | 80151.14 |
Authors | Argiriadi, M.A.,George, D.M. (deposition date: 2014-09-09, release date: 2014-10-08, Last modification date: 2015-02-04) |
Primary citation | George, D.M.,Breinlinger, E.C.,Argiriadi, M.A.,Zhang, Y.,Wang, J.,Bansal-Pakala, P.,Duignan, D.B.,Honore, P.,Lang, Q.,Mittelstadt, S.,Rundell, L.,Schwartz, A.,Sun, J.,Edmunds, J.J. Optimized Protein Kinase C theta (PKC theta ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis. J.Med.Chem., 58:333-346, 2015 Cited by PubMed: 25254961DOI: 10.1021/jm5013006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
Download full validation report