4RA5
Human Protein Kinase C THETA IN COMPLEX WITH LIGAND COMPOUND 11a (6-[(1,3-Dimethyl-azetidin-3-yl)-methyl-amino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HUMAN PROTEIN KINASE C THETA | polymer | 334 | 39596.5 | 2 | UniProt (Q04759) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | nPKC-theta |
| 2 | C, G (A, B) | (1R)-9-[(1,3-dimethylazetidin-3-yl)(methyl)amino]-1-methyl-8-phenyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one | non-polymer | 405.5 | 2 | Chemie (3L0) | |||
| 3 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A, B: 374 - 706 (UniProt: Q04759)
| PDB | External Database | Details |
|---|---|---|
| Glu 381 | Ile 381 | engineered mutation |
| Glu 538 | Thr 538 | engineered mutation |
| His 707 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79193.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 958.1 | |
| All* | Total formula weight | 80151.1 |
