4R82

Streptomyces globisporus C-1027 NADH:FAD oxidoreductase SgcE6 in complex with NAD and FAD fragments

4R82 の概要

• エントリーDOI: 10.2210/pdb4r82/pdb
• 関連するPDBエントリー: 4HX6 4OO2
• 分子名称: Oxidoreductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CALCIUM ION, ... (8 entities in total)
• 機能のキーワード: structural genomics, psi-biology, protein structure initiative, midwest center for structural genomics, mcsg, enzyme discovery for natural product biosynthesis, natpro, oxidoreductase
• 由来する生物種: Streptomyces globisporus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44614.41

構造登録者

Tan, K.,Bigelow, L.,Clancy, S.,Babnigg, G.,Bingman, C.A.,Yennamalli, R.,Lohman, J.R.,Ma, M.,Shen, B.,Phillips Jr., G.N.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG),Enzyme Discovery for Natural Product Biosynthesis (NatPro) (登録日: 2014-08-29, 公開日: 2014-10-01, 最終更新日: 2016-11-02)

• 主引用文献: Chang, C.Y.,Lohman, J.R.,Cao, H.,Tan, K.,Rudolf, J.D.,Ma, M.,Xu, W.,Bingman, C.A.,Yennamalli, R.M.,Bigelow, L.,Babnigg, G.,Yan, X.,Joachimiak, A.,Phillips, G.N.,Shen, B.; Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.; Biochemistry, 55:5142-5154, 2016; PubMed: 27560143; DOI: 10.1021/acs.biochem.6b00713

実験手法

X-RAY DIFFRACTION (1.659 Å)