4R82
Streptomyces globisporus C-1027 NADH:FAD oxidoreductase SgcE6 in complex with NAD and FAD fragments
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0010181 | molecular_function | FMN binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016646 | molecular_function | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0042602 | molecular_function | riboflavin reductase (NADPH) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0010181 | molecular_function | FMN binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016646 | molecular_function | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0042602 | molecular_function | riboflavin reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAD A 201 |
| Chain | Residue |
| A | ARG21 |
| A | HOH375 |
| A | HOH381 |
| A | HOH392 |
| A | HOH395 |
| B | LEU54 |
| B | HOH361 |
| B | HOH374 |
| A | PHE24 |
| A | GLY25 |
| A | ASN47 |
| A | HIS143 |
| A | GLY167 |
| A | NAD202 |
| A | HOH307 |
| A | HOH322 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NAD A 202 |
| Chain | Residue |
| A | ARG21 |
| A | HIS143 |
| A | NAD201 |
| A | FAD209 |
| A | HOH307 |
| A | HOH375 |
| B | ASP16 |
| B | CA203 |
| B | HOH308 |
| B | HOH361 |
| B | HOH374 |
| B | HOH397 |
| B | HOH399 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 203 |
| Chain | Residue |
| A | ASP16 |
| A | HOH350 |
| A | HOH365 |
| B | NAD202 |
| B | HOH353 |
| B | HOH398 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 204 |
| Chain | Residue |
| A | ARG17 |
| A | ARG21 |
| B | ARG17 |
| B | LEU54 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 205 |
| Chain | Residue |
| A | SER165 |
| A | GLY166 |
| A | ARG170 |
| A | HOH328 |
| B | ARG159 |
| B | GLU160 |
| B | CA204 |
| B | HOH311 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 206 |
| Chain | Residue |
| A | GLN88 |
| A | LYS90 |
| A | ALA91 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 207 |
| Chain | Residue |
| A | GLU139 |
| A | GLY141 |
| B | HIS135 |
| B | ARG136 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 208 |
| Chain | Residue |
| A | PHE49 |
| A | THR50 |
| A | HOH306 |
| B | PHE49 |
| B | THR50 |
| B | HOH425 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FAD A 209 |
| Chain | Residue |
| A | MSE44 |
| A | THR45 |
| A | ALA46 |
| A | ASN47 |
| A | SER48 |
| A | CYS62 |
| A | VAL63 |
| A | GLY64 |
| A | ALA67 |
| A | ALA96 |
| A | HIS98 |
| A | PHE164 |
| A | NAD202 |
| A | HOH310 |
| A | HOH335 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NAD B 201 |
| Chain | Residue |
| A | LEU54 |
| A | HOH380 |
| B | ARG21 |
| B | PHE24 |
| B | ASN47 |
| B | HIS143 |
| B | GLY167 |
| B | NAD202 |
| B | HOH310 |
| B | HOH338 |
| B | HOH375 |
| B | HOH389 |
| B | HOH398 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NAD B 202 |
| Chain | Residue |
| A | ASP16 |
| A | CA203 |
| A | HOH350 |
| B | ARG21 |
| B | HIS143 |
| B | NAD201 |
| B | FAD207 |
| B | HOH353 |
| B | HOH398 |
| B | HOH409 |
| B | HOH420 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 203 |
| Chain | Residue |
| A | NAD202 |
| B | ASP16 |
| B | HOH324 |
| B | HOH374 |
| B | HOH397 |
| B | HOH399 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 204 |
| Chain | Residue |
| A | ACT205 |
| A | HOH328 |
| A | HOH411 |
| B | PRO157 |
| B | ARG159 |
| B | HOH311 |
| B | HOH400 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 205 |
| Chain | Residue |
| A | ARG17 |
| A | LEU54 |
| B | ARG17 |
| B | ARG21 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 206 |
| Chain | Residue |
| B | LEU122 |
| B | HIS129 |
| B | THR154 |
| B | TRP156 |
| B | HOH331 |
| site_id | BC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FAD B 207 |
| Chain | Residue |
| B | MSE44 |
| B | THR45 |
| B | ALA46 |
| B | ASN47 |
| B | SER48 |
| B | CYS62 |
| B | VAL63 |
| B | GLY64 |
| B | ALA67 |
| B | VAL68 |
| B | ALA96 |
| B | PHE164 |
| B | NAD202 |
| B | HOH371 |
| B | HOH373 |
| B | HOH391 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27560143","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R82","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
