4HX6

Streptomyces globisporus C-1027 NADH:FAD oxidoreductase SgcE6

Summary for 4HX6

• Entry DOI: 10.2210/pdb4hx6/pdb
• Related: 4OO2 4R82
• Descriptor: Oxidoreductase, SULFATE ION, ACETATE ION, ... (4 entities in total)
• Functional Keywords: structural genomics, psi-biology, protein structure initiative, midwest center for structural genomics, mcsg, enzyme discovery for natural product biosynthesis, natpro, oxidoreductase
• Biological source: Streptomyces globisporus
• Total number of polymer chains: 8
• Total formula weight: 160471.17

Authors

Tan, K.,Bigelow, L.,Clancy, S.,Babnigg, G.,Bingman, C.A.,Yennamalli, R.,Lohman, J.R.,Ma, M.,Shen, B.,Phillips Jr., G.N.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG),Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2012-11-09, release date: 2012-11-28, Last modification date: 2016-12-07)

• Primary citation: Chang, C.Y.,Lohman, J.R.,Cao, H.,Tan, K.,Rudolf, J.D.,Ma, M.,Xu, W.,Bingman, C.A.,Yennamalli, R.M.,Bigelow, L.,Babnigg, G.,Yan, X.,Joachimiak, A.,Phillips, G.N.,Shen, B.; Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.; Biochemistry, 55:5142-5154, 2016; PubMed: 27560143; DOI: 10.1021/acs.biochem.6b00713

Experimental method

X-RAY DIFFRACTION (1.89 Å)