4R76

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor

4R76 の概要

• エントリーDOI: 10.2210/pdb4r76/pdb
• 関連するPDBエントリー: 3EBG 4R5T 4R5V 4R5X 4R6T 4R7M
• 分子名称: M17 family aminopeptidase, ZINC ION, CARBONATE ION, ... (7 entities in total)
• 機能のキーワード: protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum fcb1/columbia
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 715260.52

構造登録者

Drinkwater, N.,Mcgowan, S. (登録日: 2014-08-27, 公開日: 2014-10-29, 最終更新日: 2023-09-20)

• 主引用文献: Mistry, S.N.,Drinkwater, N.,Ruggeri, C.,Sivaraman, K.K.,Loganathan, S.,Fletcher, S.,Drag, M.,Paiardini, A.,Avery, V.M.,Scammells, P.J.,McGowan, S.; Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors.; J.Med.Chem., 57:9168-9183, 2014; PubMed: 25299353; DOI: 10.1021/jm501323a

実験手法

X-RAY DIFFRACTION (2.5 Å)