Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4R76

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0019538	biological_process	protein metabolic process
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0019538	biological_process	protein metabolic process
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0019538	biological_process	protein metabolic process
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0070006	molecular_function	metalloaminopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0019538	biological_process	protein metabolic process
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
E	0070006	molecular_function	metalloaminopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0019538	biological_process	protein metabolic process
F	0030145	molecular_function	manganese ion binding
F	0046872	molecular_function	metal ion binding
F	0070006	molecular_function	metalloaminopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0019538	biological_process	protein metabolic process
G	0030145	molecular_function	manganese ion binding
G	0046872	molecular_function	metal ion binding
G	0070006	molecular_function	metalloaminopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0019538	biological_process	protein metabolic process
H	0030145	molecular_function	manganese ion binding
H	0046872	molecular_function	metal ion binding
H	0070006	molecular_function	metalloaminopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0019538	biological_process	protein metabolic process
I	0030145	molecular_function	manganese ion binding
I	0046872	molecular_function	metal ion binding
I	0070006	molecular_function	metalloaminopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0019538	biological_process	protein metabolic process
J	0030145	molecular_function	manganese ion binding
J	0046872	molecular_function	metal ion binding
J	0070006	molecular_function	metalloaminopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0019538	biological_process	protein metabolic process
K	0030145	molecular_function	manganese ion binding
K	0046872	molecular_function	metal ion binding
K	0070006	molecular_function	metalloaminopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0019538	biological_process	protein metabolic process
L	0030145	molecular_function	manganese ion binding
L	0046872	molecular_function	metal ion binding
L	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	LYS374
A	ASP379
A	ASP399
A	GLU461
A	ZN1003
A	R5X1004
A	HOH1270

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 A 1002

Chain	Residue
A	GLY462
A	ARG463
A	LEU487
A	R5X1004
A	LYS374
A	ALA460

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1003

Chain	Residue
A	ASP379
A	ASP459
A	GLU461
A	ZN1001
A	R5X1004

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE R5X A 1004

Chain	Residue
A	LYS374
A	ASP379
A	LYS386
A	MET392
A	ASP459
A	GLU461
A	LEU487
A	THR488
A	GLY489
A	LEU492
A	ALA577
A	ZN1001
A	CO31002
A	ZN1003
A	HOH1144
A	HOH1270

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	SER435
A	LYS436
B	SER435
B	LYS436
C	SER435
C	LYS436

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1006

Chain	Residue
A	TYR244
A	ASP249
A	TYR292
A	SER295
A	HOH1174
C	TYR541

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN B 1001

Chain	Residue
B	LYS374
B	ASP379
B	ASP399
B	GLU461
B	ZN1003
B	R5X1004
B	HOH1225

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 B 1002

Chain	Residue
B	LYS374
B	ALA460
B	GLU461
B	GLY462
B	ARG463
B	LEU487
B	R5X1004

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 1003

Chain	Residue
B	ASP379
B	ASP459
B	GLU461
B	ZN1001
B	R5X1004

site_id	BC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE R5X B 1004

Chain	Residue
B	LYS374
B	ASP379
B	LYS386
B	PHE398
B	ASN457
B	ASP459
B	GLU461
B	LEU487
B	THR488
B	GLY489
B	ALA577
B	ZN1001
B	CO31002
B	ZN1003
B	HOH1134
B	HOH1225

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE B 1005

Chain	Residue
B	TYR103
B	GLU316
B	LYS320
B	1PE1006

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE B 1006

Chain	Residue
B	TYR103
B	HIS108
B	PHE289
B	LYS320
B	TYR411
B	1PE1005

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN C 1001

Chain	Residue
C	LYS374
C	ASP379
C	ASP399
C	GLU461
C	ZN1003
C	R5X1004
C	HOH1255

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 C 1002

Chain	Residue
C	ALA460
C	GLY462
C	ARG463
C	LEU487
C	R5X1004
C	LYS374

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 1003

Chain	Residue
C	ASP379
C	ASP459
C	GLU461
C	ZN1001
C	R5X1004

site_id	BC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE R5X C 1004

Chain	Residue
C	LYS374
C	ASP379
C	LYS386
C	MET392
C	PHE398
C	ASN457
C	ASP459
C	GLU461
C	LEU487
C	THR488
C	GLY489
C	SER554
C	ALA577
C	ZN1001
C	CO31002
C	ZN1003
C	HOH1251
C	HOH1255

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN D 1001

Chain	Residue
D	LYS374
D	ASP379
D	ASP399
D	GLU461
D	ZN1003
D	R5X1004
D	HOH1274

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 D 1002

Chain	Residue
D	LYS374
D	ALA460
D	GLY462
D	ARG463
D	LEU487
D	R5X1004

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 1003

Chain	Residue
D	ASP379
D	ASP459
D	GLU461
D	ZN1001
D	R5X1004

site_id	CC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE R5X D 1004

Chain	Residue
D	LYS374
D	ASP379
D	LYS386
D	ASN457
D	ASP459
D	GLU461
D	LEU487
D	THR488
D	GLY489
D	LEU492
D	SER554
D	ALA577
D	ZN1001
D	CO31002
D	ZN1003
D	HOH1274

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN E 1001

Chain	Residue
E	LYS374
E	ASP379
E	ASP399
E	GLU461
E	ZN1003
E	R5X1004
E	HOH1157

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 E 1002

Chain	Residue
E	LYS374
E	ALA460
E	GLY462
E	ARG463
E	LEU487
E	R5X1004

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN E 1003

Chain	Residue
E	ASP379
E	LYS386
E	ASP459
E	GLU461
E	ZN1001
E	R5X1004

site_id	CC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE R5X E 1004

Chain	Residue
E	LYS374
E	ASP379
E	LYS386
E	PHE398
E	ASN457
E	ASP459
E	GLU461
E	LEU487
E	THR488
E	GLY489
E	ZN1001
E	CO31002
E	ZN1003
E	HOH1141
E	HOH1157

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 1005

Chain	Residue
D	SER435
D	LYS436
E	SER435
E	LYS436
F	SER435
F	LYS436

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE E 1006

Chain	Residue
E	TYR103
E	HIS108
E	LEU321
E	TYR411

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE E 1007

Chain	Residue
E	ASN511

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN F 1001

Chain	Residue
F	LYS374
F	ASP379
F	ASP399
F	GLU461
F	ZN1003
F	R5X1004
F	HOH1219

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 1008

Chain	Residue
E	GLU102
E	TYR103
E	ASN104
E	HOH1178

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 F 1002

Chain	Residue
F	LYS374
F	ALA460
F	GLY462
F	ARG463
F	LEU487
F	R5X1004

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 1003

Chain	Residue
F	ASP379
F	ASP459
F	GLU461
F	ZN1001
F	R5X1004

site_id	DC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE R5X F 1004

Chain	Residue
F	LYS374
F	ASP379
F	LYS386
F	MET392
F	PHE398
F	ASN457
F	ASP459
F	GLU461
F	LEU487
F	THR488
F	GLY489
F	LEU492
F	ALA577
F	ZN1001
F	CO31002
F	ZN1003
F	HOH1219

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE F 1005

Chain	Residue
F	TYR103
F	LYS320
F	SO41008

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE F 1006

Chain	Residue
F	TYR103
F	ASN104
F	HIS108
F	LYS320
F	TYR411
F	HOH1142

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE F 1007

Chain	Residue
F	SER93
F	LEU94
F	ASP95

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 1008

Chain	Residue
F	ILE101
F	TYR103
F	ASN104
F	1PE1005
F	HOH1172

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN G 1001

Chain	Residue
G	LYS374
G	ASP379
G	ASP399
G	GLU461
G	ZN1003
G	R5X1004
G	HOH1148

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 G 1002

Chain	Residue
G	LYS374
G	ALA460
G	GLY462
G	ARG463
G	LEU487
G	R5X1004

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 1003

Chain	Residue
G	ASP379
G	ASP459
G	GLU461
G	ZN1001
G	R5X1004

site_id	EC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE R5X G 1004

Chain	Residue
G	LYS374
G	ASP379
G	LYS386
G	MET396
G	ASN457
G	ASP459
G	GLU461
G	LEU487
G	THR488
G	GLY489
G	LEU492
G	SER554
G	ALA577
G	ZN1001
G	CO31002
G	ZN1003
G	HOH1148

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE G 1005

Chain	Residue
G	TYR103
G	HIS108
G	PHE289
G	LYS320
G	TYR411

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE G 1006

Chain	Residue
G	TYR103
G	GLU316
G	GLN319
G	LYS320
G	HOH1244

site_id	EC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN H 1001

Chain	Residue
H	LYS374
H	ASP379
H	ASP399
H	GLU461
H	ZN1003
H	R5X1004
H	HOH1233

site_id	EC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 H 1002

Chain	Residue
H	LYS374
H	ALA460
H	GLY462
H	ARG463
H	LEU487
H	R5X1004

site_id	EC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 1003

Chain	Residue
H	ASP379
H	ASP459
H	GLU461
H	ZN1001
H	R5X1004

site_id	FC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE R5X H 1004

Chain	Residue
H	LYS374
H	ASP379
H	LYS386
H	ASN457
H	ASP459
H	GLU461
H	LEU487
H	THR488
H	GLY489
H	ALA577
H	ZN1001
H	CO31002
H	ZN1003
H	HOH1136
H	HOH1233

site_id	FC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 1005

Chain	Residue
G	SER435
G	LYS436
H	SER435
H	LYS436
I	SER435
I	LYS436

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE H 1006

Chain	Residue
H	TYR103
H	ASN104
H	HIS108
H	LYS320
H	TYR411

site_id	FC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN I 1001

Chain	Residue
I	LYS374
I	ASP379
I	ASP399
I	GLU461
I	ZN1003
I	R5X1004
I	HOH1242

site_id	FC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 I 1002

Chain	Residue
I	LYS374
I	ALA460
I	GLU461
I	GLY462
I	ARG463
I	LEU487
I	R5X1004

site_id	FC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN I 1003

Chain	Residue
I	ASP379
I	ASP459
I	GLU461
I	ZN1001
I	R5X1004

site_id	FC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE R5X I 1004

Chain	Residue
I	LYS374
I	ASP379
I	LYS386
I	MET392
I	PHE398
I	ASP459
I	GLU461
I	ARG463
I	LEU487
I	THR488
I	GLY489
I	ALA577
I	ZN1001
I	CO31002
I	ZN1003
I	HOH1242

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE I 1005

Chain	Residue
I	TYR103
I	GLU316
I	LYS320

site_id	FC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE I 1006

Chain	Residue
I	TYR103
I	ASN104
I	PHE289
I	LYS320
I	TYR411

site_id	GC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN J 1001

Chain	Residue
J	LYS374
J	ASP379
J	ASP399
J	GLU461
J	ZN1003
J	R5X1004
J	HOH1271

site_id	GC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 J 1002

Chain	Residue
J	LYS374
J	ALA460
J	GLY462
J	ARG463
J	LEU487
J	R5X1004

site_id	GC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN J 1003

Chain	Residue
J	ASP379
J	ASP459
J	GLU461
J	ZN1001
J	R5X1004

site_id	GC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE R5X J 1004

Chain	Residue
J	LYS374
J	ASP379
J	LYS386
J	MET392
J	ASP459
J	GLU461
J	LEU487
J	THR488
J	GLY489
J	ALA577
J	ZN1001
J	CO31002
J	ZN1003

site_id	GC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE J 1005

Chain	Residue
J	TYR103
J	HIS108
J	PHE289
J	TYR411

site_id	GC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN K 1001

Chain	Residue
K	LYS374
K	ASP379
K	ASP399
K	GLU461
K	ZN1003
K	R5X1004
K	HOH1255

site_id	GC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 K 1002

Chain	Residue
K	LYS374
K	ALA460
K	GLY462
K	ARG463
K	LEU487
K	R5X1004

site_id	GC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN K 1003

Chain	Residue
K	ASP379
K	ASP459
K	GLU461
K	ZN1001
K	R5X1004

site_id	GC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE R5X K 1004

Chain	Residue
K	LYS374
K	ASP379
K	LYS386
K	MET392
K	PHE398
K	ASP459
K	GLU461
K	LEU487
K	THR488
K	GLY489
K	LEU492
K	SER554
K	ZN1001
K	CO31002
K	ZN1003
K	HOH1181
K	HOH1255
K	HOH1262

site_id	HC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 K 1005

Chain	Residue
J	SER435
J	LYS436
K	SER435
K	LYS436
L	SER435
L	LYS436

site_id	HC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE K 1006

Chain	Residue
K	TYR103
K	HIS108
K	PHE289
K	TYR411

site_id	HC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN L 1001

Chain	Residue
L	LYS374
L	ASP379
L	ASP399
L	GLU461
L	ZN1003
L	R5X1004
L	HOH1240

site_id	HC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 L 1002

Chain	Residue
L	LYS374
L	ALA460
L	GLY462
L	ARG463
L	LEU487
L	R5X1004

site_id	HC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN L 1003

Chain	Residue
L	ASP379
L	ASP459
L	GLU461
L	ZN1001
L	R5X1004

site_id	HC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE R5X L 1004

Chain	Residue
L	LYS374
L	ASP379
L	LYS386
L	PHE398
L	ASN457
L	ASP459
L	GLU461
L	LEU487
L	THR488
L	GLY489
L	SER554
L	ALA577
L	ZN1001
L	CO31002
L	ZN1003
L	HOH1240

site_id	HC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE L 1005

Chain	Residue
L	TYR103
L	ASN104
L	HIS108
L	TYR411

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN457-LEU464

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:P00727

Chain	Residue	Details
A	LYS386
E	ARG463
F	LYS386
F	ARG463
G	LYS386
G	ARG463
H	LYS386
H	ARG463
I	LYS386
I	ARG463
J	LYS386
A	ARG463
J	ARG463
K	LYS386
K	ARG463
L	LYS386
L	ARG463
B	LYS386
B	ARG463
C	LYS386
C	ARG463
D	LYS386
D	ARG463
E	LYS386

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269\|PubMed:20133789, ECO:0000269\|PubMed:21844374, ECO:0000269\|PubMed:23713488, ECO:0000269\|PubMed:25299353, ECO:0000269\|PubMed:25645579, ECO:0000269\|PubMed:35691342, ECO:0000269\|Ref.13, ECO:0000312\|PDB:3T8W, ECO:0007744\|PDB:3KQX, ECO:0007744\|PDB:3KQZ, ECO:0007744\|PDB:3KR4, ECO:0007744\|PDB:3KR5, ECO:0007744\|PDB:4K3N, ECO:0007744\|PDB:4R6T, ECO:0007744\|PDB:4R76, ECO:0007744\|PDB:4R7M, ECO:0007744\|PDB:4X2T, ECO:0007744\|PDB:7RIE, ECO:0007744\|PDB:7T3V

Chain	Residue	Details
A	LYS374
D	LYS374
D	ASP379
D	GLU461
E	LYS374
E	ASP379
E	GLU461
F	LYS374
F	ASP379
F	GLU461
G	LYS374
A	ASP379
G	ASP379
G	GLU461
H	LYS374
H	ASP379
H	GLU461
I	LYS374
I	ASP379
I	GLU461
J	LYS374
J	ASP379
A	GLU461
J	GLU461
K	LYS374
K	ASP379
K	GLU461
L	LYS374
L	ASP379
L	GLU461
B	LYS374
B	ASP379
B	GLU461
C	LYS374
C	ASP379
C	GLU461

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:20133789, ECO:0000305\|PubMed:23713488, ECO:0007744\|PDB:3KR5, ECO:0007744\|PDB:4K3N

Chain	Residue	Details
A	LYS386
J	LYS386
K	LYS386
L	LYS386
B	LYS386
C	LYS386
D	LYS386
E	LYS386
F	LYS386
G	LYS386
H	LYS386
I	LYS386

site_id	SWS_FT_FI4
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269\|PubMed:35691342, ECO:0007744\|PDB:7SRV

Chain	Residue	Details
A	ASP394
D	ASP394
D	MET396
D	ASP399
E	ASP394
E	MET396
E	ASP399
F	ASP394
F	MET396
F	ASP399
G	ASP394
A	MET396
G	MET396
G	ASP399
H	ASP394
H	MET396
H	ASP399
I	ASP394
I	MET396
I	ASP399
J	ASP394
J	MET396
A	ASP399
J	ASP399
K	ASP394
K	MET396
K	ASP399
L	ASP394
L	MET396
L	ASP399
B	ASP394
B	MET396
B	ASP399
C	ASP394
C	MET396
C	ASP399

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:20133789, ECO:0000269\|PubMed:21844374, ECO:0000269\|PubMed:23713488, ECO:0000269\|PubMed:25299353, ECO:0000269\|PubMed:25645579, ECO:0000269\|PubMed:35691342, ECO:0000269\|Ref.13, ECO:0000312\|PDB:3KQZ, ECO:0000312\|PDB:3T8W, ECO:0007744\|PDB:3KR4, ECO:0007744\|PDB:3KR5, ECO:0007744\|PDB:4K3N, ECO:0007744\|PDB:4R6T, ECO:0007744\|PDB:4R76, ECO:0007744\|PDB:4R7M, ECO:0007744\|PDB:4X2T, ECO:0007744\|PDB:7RIE, ECO:0007744\|PDB:7T3V

Chain	Residue	Details
A	ASP459
J	ASP459
K	ASP459
L	ASP459
B	ASP459
C	ASP459
D	ASP459
E	ASP459
F	ASP459
G	ASP459
H	ASP459
I	ASP459

site_id	SWS_FT_FI6
Number of Residues	12
Details	SITE: Essential for hexamer stabilization => ECO:0000269\|PubMed:35691342

Chain	Residue	Details
A	LYS386
J	LYS386
K	LYS386
L	LYS386
B	LYS386
C	LYS386
D	LYS386
E	LYS386
F	LYS386
G	LYS386
H	LYS386
I	LYS386

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)