4R5M
Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid
Summary for 4R5M
Entry DOI | 10.2210/pdb4r5m/pdb |
Related | 4R3N 4R3W 4R41 4R4J 4R51 4R54 4R5H |
Descriptor | Aspartate-semialdehyde dehydrogenase 1, SODIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | rossmann fold, oxidoreductase, nadp, cypoplasm |
Biological source | Vibrio cholerae O1 |
Total number of polymer chains | 2 |
Total formula weight | 84745.07 |
Authors | Pavlovsky, A.G.,Thangavelu, B.,Bhansali, P.,Viola, R.E. (deposition date: 2014-08-21, release date: 2014-12-10, Last modification date: 2023-09-20) |
Primary citation | Pavlovsky, A.G.,Thangavelu, B.,Bhansali, P.,Viola, R.E. A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallogr.,Sect.D, 70:3244-3252, 2014 Cited by PubMed: 25478842DOI: 10.1107/S1399004714023979 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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