4R26

Crystal structure of human Fab PGT124, a broadly neutralizing and potent HIV-1 neutralizing antibody

Summary for 4R26

• Entry DOI: 10.2210/pdb4r26/pdb
• Descriptor: PGR124-Light Chain, PGT124-Heavy Chain, GLYCEROL, ... (4 entities in total)
• Functional Keywords: immune system, igg fold, antibody, hiv-1 binding
• Biological source: Nomascus leucogenys (Northern white-cheeked gibbon); More
• Cellular location: Secreted : P0DOY3 P0DOX5
• Total number of polymer chains: 2
• Total formula weight: 48793.39

Authors

Garces, F.,Kong, L.,Wilson, I.A. (deposition date: 2014-08-08, release date: 2014-10-08, Last modification date: 2017-06-21)

• Primary citation: Garces, F.,Sok, D.,Kong, L.,McBride, R.,Kim, H.J.,Saye-Francisco, K.F.,Julien, J.P.,Hua, Y.,Cupo, A.,Moore, J.P.,Paulson, J.C.,Ward, A.B.,Burton, D.R.,Wilson, I.A.; Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies.; Cell(Cambridge,Mass.), 159:69-79, 2014; PubMed: 25259921; DOI: 10.1016/j.cell.2014.09.009

Experimental method

X-RAY DIFFRACTION (2.4969 Å)