4R1V
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors
Summary for 4R1V
Entry DOI | 10.2210/pdb4r1v/pdb |
Related | 4R1Y |
Descriptor | Hepatocyte growth factor receptor, 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile, GAMMA-BUTYROLACTONE, ... (4 entities in total) |
Functional Keywords | protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 33742.21 |
Authors | Blaukat, A.,Bladt, F.,Friese-Hamim, M.,Knuehl, C.,Fittschen, C.,Graedler, U.,Meyring, M.,Dorsch, D.,Stieber, F.,Schadt, O. (deposition date: 2014-08-07, release date: 2015-03-18, Last modification date: 2024-02-28) |
Primary citation | Dorsch, D.,Schadt, O.,Stieber, F.,Meyring, M.,Gradler, U.,Bladt, F.,Friese-Hamim, M.,Knuhl, C.,Pehl, U.,Blaukat, A. Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors. Bioorg.Med.Chem.Lett., 25:1597-1602, 2015 Cited by PubMed: 25736998DOI: 10.1016/j.bmcl.2015.02.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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