4R1V
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 291 | 32991.4 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
| 2 | B (A) | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | non-polymer | 492.6 | 1 | Chemie (3E8) | |||
| 3 | C, D, E (A) | GAMMA-BUTYROLACTONE | non-polymer | 86.1 | 3 | Chemie (GBL) | |||
| 4 | F (A) | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32991.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 750.8 | |
| All* | Total formula weight | 33742.2 |
