4QYD

Crystal Structure of the human BRPF1 bromodomain in complex with a histone H4K12ac peptide

Summary for 4QYD

• Entry DOI: 10.2210/pdb4qyd/pdb
• Related: 4QYL
• Descriptor: Peregrin, Histone H4 (3 entities in total)
• Functional Keywords: bromodomain-phd finger protein 1 (brpf1), histone acetyltransferase (hat), monocytic leukemia zinc-finger (moz), epigenetics, chromatin reader, bromodomain, histone post-transcriptional modification (ptm) reader domain, histone h4 acetylated at lysine 14, acetyllysine, nucleus, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P55201 P62805
• Total number of polymer chains: 2
• Total formula weight: 15037.24

Authors

Lubula, M.Y.,Glass, K.C. (deposition date: 2014-07-24, release date: 2014-09-24, Last modification date: 2023-12-06)

• Primary citation: Lubula, M.Y.,Eckenroth, B.E.,Carlson, S.,Poplawski, A.,Chruszcz, M.,Glass, K.C.; Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.; Febs Lett., 588:3844-3854, 2014; PubMed: 25281266; DOI: 10.1016/j.febslet.2014.09.028

Experimental method

X-RAY DIFFRACTION (1.94 Å)