4QXO
Crystal structure of hSTING(group2) in complex with DMXAA
Summary for 4QXO
Entry DOI | 10.2210/pdb4qxo/pdb |
Related | 4QXP 4QXQ 4QXR |
Descriptor | Stimulator of interferon genes protein, (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid (3 entities in total) |
Functional Keywords | immune system, innate immunity, cgamp binding, membrane |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: Q86WV6 |
Total number of polymer chains | 1 |
Total formula weight | 21925.64 |
Authors | Gao, P.,Patel, D.J. (deposition date: 2014-07-21, release date: 2014-09-10, Last modification date: 2024-02-28) |
Primary citation | Gao, P.,Zillinger, T.,Wang, W.,Ascano, M.,Dai, P.,Hartmann, G.,Tuschl, T.,Deng, L.,Barchet, W.,Patel, D.J. Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA. Cell Rep, 8:1668-1676, 2014 Cited by PubMed: 25199835DOI: 10.1016/j.celrep.2014.08.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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