Crystal Structure of RON Sema-PSI-IPT1 extracellular domains in complex with MSP beta-chain

Summary for 4QT8

Related4FWW 2ASU
DescriptorMacrophage-stimulating protein receptor, Hepatocyte growth factor-like protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywordsgrowth factor receptor/growth factor, receptor-ligand complex, ron receptor tyrosine kinase, macrophage stimulating protein, hydrolase-signaling protein complex, hydrolase/signaling protein
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total molecular weight201659.3
Herzberg, O.,Chao, K.L. (deposition date: 2014-07-07, release date: 2014-09-17, Last modification date: 2020-07-29)
Primary citation
Chao, K.L.,Gorlatova, N.V.,Eisenstein, E.,Herzberg, O.
Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein.
J.Biol.Chem., 289:29948-29960, 2014
PubMed: 25193665 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.594341
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24610 4.8% 7.6% 0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-11-25