4QT8
Crystal Structure of RON Sema-PSI-IPT1 extracellular domains in complex with MSP beta-chain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Macrophage-stimulating protein receptor | polymer | 669 | 71987.4 | 2 | UniProt (Q04912) Pfam (PF01403) Pfam (PF01437) Pfam (PF01833) In PDB | Homo sapiens (human) | MSP receptor, CDw136, Protein-tyrosine kinase 8, p185-Ron, RON receptor tyrosine kinase |
2 | C, D | Hepatocyte growth factor-like protein | polymer | 253 | 28336.7 | 2 | UniProt (P26927) Pfam (PF00089) In PDB | Homo sapiens (human) | Macrophage stimulatory protein, Macrophage-stimulating protein, MSP |
3 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
4 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) |
Sequence modifications
B, A: 25 - 683 (UniProt: Q04912)
C, D: 465 - 711 (UniProt: P26927)
PDB | External Database | Details |
---|---|---|
Arg 23 | - | expression tag |
Ser 24 | - | expression tag |
Gly 209 | Ala 209 | conflict |
Leu 306 | Arg 306 | engineered mutation |
Val 307 | Arg 307 | engineered mutation |
Pro 308 | Arg 308 | engineered mutation |
Ser 311 | Ala 311 | engineered mutation |
Gln 322 | Arg 322 | engineered mutation |
Thr 684 | - | expression tag |
Gly 685 | - | expression tag |
His 686 | - | expression tag |
His 687 | - | expression tag |
His 688 | - | expression tag |
His 689 | - | expression tag |
His 690 | - | expression tag |
His 691 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 672 | Cys 672 | engineered mutation |
His 712 | - | expression tag |
His 713 | - | expression tag |
His 714 | - | expression tag |
His 715 | - | expression tag |
His 716 | - | expression tag |
His 717 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 200648.4 | |
Branched | Number of molecules | 2 |
Total formula weight | 1010.9 | |
All* | Total formula weight | 201659.3 |