4QIR

Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-2-(pyridin-3-yl)ethylGlyP[CH2]Phe

4QIR の概要

• エントリーDOI: 10.2210/pdb4qir/pdb
• 関連するPDBエントリー: 4PU2 4PVB 4PW4 4QHP 4QME 4QPE
• 分子名称: Aminopeptidase N, 3-{[(R)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(S)-2-benzylpropanoic acid, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: alanine aminopeptidase, aminopeptidase n, m1 family peptidases, 3-{[(r)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(s)-2-benzylpropanoic acid, hydrolase
• 由来する生物種: Neisseria meningitidis MC58
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 100108.11

構造登録者

Nocek, B.,Joachimiak, A.,Berlicki, L.,Vassiliou, S.,Mucha, A. (登録日: 2014-06-01, 公開日: 2014-09-24, 最終更新日: 2023-12-06)

• 主引用文献: Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A.; Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.; J.Med.Chem., 57:8140-8151, 2014; PubMed: 25192493; DOI: 10.1021/jm501071f

実験手法

X-RAY DIFFRACTION (1.701 Å)