4QIN
Structure of the human smoothened receptor in complex with SAG1.5
Summary for 4QIN
Entry DOI | 10.2210/pdb4qin/pdb |
Related | 4O9R 4QIM |
Descriptor | Smoothened homolog/Soluble cytochrome b562 chimeric protein, 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide (3 entities in total) |
Functional Keywords | human smoothened receptor, agonist, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, signaling protein |
Biological source | Homo sapiens More |
Cellular location | Membrane ; Multi-pass membrane protein : Q99835 |
Total number of polymer chains | 1 |
Total formula weight | 52921.24 |
Authors | Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.-P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2014-05-31, release date: 2014-07-23, Last modification date: 2023-09-20) |
Primary citation | Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun, 5:4355-4355, 2014 Cited by PubMed: 25008467DOI: 10.1038/ncomms5355 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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