4QIM

Structure of the human smoothened receptor in complex with ANTA XV

4QIM の概要

• エントリーDOI: 10.2210/pdb4qim/pdb
• 関連するPDBエントリー: 4O9R 4QIN
• 分子名称: Smoothened homolog/Soluble cytochrome b562 chimeric protein, 2-{6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propan-2-ol, ZINC ION, ... (4 entities in total)
• 機能のキーワード: human smoothened receptor, antitumor agent, novel protein engineering, gpcr network, psi-biology, structural genomics, membrane protein, gpcr, membrane, signaling protein
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Membrane ; Multi-pass membrane protein : Q99835
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52900.16

構造登録者

Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.-P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C.,GPCR Network (GPCR) (登録日: 2014-05-31, 公開日: 2014-07-23, 最終更新日: 2023-09-20)

• 主引用文献: Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C.; Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.; Nat Commun, 5:4355-4355, 2014; PubMed: 25008467; DOI: 10.1038/ncomms5355

実験手法

X-RAY DIFFRACTION (2.61 Å)