4QHO

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with CCO10

Summary for 4QHO

Entry DOI	10.2210/pdb4qho/pdb
Related	3LFM 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7
Descriptor	Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, N-{[3-hydroxy-6-(naphthalen-1-yl)pyridin-2-yl]carbonyl}glycine, ... (4 entities in total)
Functional Keywords	jelly-roll motif, oxidoreductase, dioxygenase, double-stranded beta helix fold, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q9C0B1
Total number of polymer chains	1
Total formula weight	57210.77
Authors	Aik, W.S.,Clunie-O'Connor, C.,McDonough, M.A.,Schofield, C.J. (deposition date: 2014-05-28, release date: 2015-06-03, Last modification date: 2023-11-08)
Primary citation	Shishodia, S.,Demetriades, M.,Zhang, D.,Tam, N.Y.,Maheswaran, P.,Clunie-O'Connor, C.,Tumber, A.,Leung, I.K.H.,Ng, Y.M.,Leissing, T.M.,El-Sagheer, A.H.,Salah, E.,Brown, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J. Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J.Med.Chem., 64:16609-16625, 2021 Cited by PubMed: 34762429 DOI: 10.1021/acs.jmedchem.1c01204 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation