4QHO

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with CCO10

4QHO の概要

• エントリーDOI: 10.2210/pdb4qho/pdb
• 関連するPDBエントリー: 3LFM 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7
• 分子名称: Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, N-{[3-hydroxy-6-(naphthalen-1-yl)pyridin-2-yl]carbonyl}glycine, ... (4 entities in total)
• 機能のキーワード: jelly-roll motif, oxidoreductase, dioxygenase, double-stranded beta helix fold, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q9C0B1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57210.77

構造登録者

Aik, W.S.,Clunie-O'Connor, C.,McDonough, M.A.,Schofield, C.J. (登録日: 2014-05-28, 公開日: 2015-06-03, 最終更新日: 2023-11-08)

• 主引用文献: Shishodia, S.,Demetriades, M.,Zhang, D.,Tam, N.Y.,Maheswaran, P.,Clunie-O'Connor, C.,Tumber, A.,Leung, I.K.H.,Ng, Y.M.,Leissing, T.M.,El-Sagheer, A.H.,Salah, E.,Brown, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J.; Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.; J.Med.Chem., 64:16609-16625, 2021; PubMed: 34762429; DOI: 10.1021/acs.jmedchem.1c01204

実験手法

X-RAY DIFFRACTION (2.37 Å)