4QG0
Crystal structure of the tetrameric dGTP/dUTP-bound SAMHD1 (RN206) mutant catalytic core
Summary for 4QG0
Entry DOI | 10.2210/pdb4qg0/pdb |
Related | 4BZB 4BZC 4MZ7 4QFX 4QFY 4QFZ 4QG1 4QG2 4QG4 |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DEOXYURIDINE-5'-TRIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | deoxynucleoside triphosphate triphosphohydrolase, 2'-deoxynucleotide-5'-triphosphate, hiv restriction factor, dntpase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q9Y3Z3 |
Total number of polymer chains | 4 |
Total formula weight | 259711.56 |
Authors | Koharudin, L.M.I.,Wu, Y.,DeLucia, M.,Mehrens, J.,Gronenborn, A.M.,Ahn, J. (deposition date: 2014-05-22, release date: 2014-10-15, Last modification date: 2023-09-20) |
Primary citation | Koharudin, L.M.,Wu, Y.,DeLucia, M.,Mehrens, J.,Gronenborn, A.M.,Ahn, J. Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates. J.Biol.Chem., 289:32617-32627, 2014 Cited by PubMed: 25288794DOI: 10.1074/jbc.M114.591958 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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