4QFX

Crystal structure of the tetrameric dGTP/dATP-bound SAMHD1 (RN206) mutant catalytic core

Summary for 4QFX

Entry DOI	10.2210/pdb4qfx/pdb
Related	4BZB 4BZC 4MZ7 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	deoxynucleoside triphosphate triphosphohydrolase, 2'-deoxynucleotide-5'-triphosphate, hiv restriction factor, dntpase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q9Y3Z3
Total number of polymer chains	4
Total formula weight	259922.12
Authors	Koharudin, L.M.I.,Wu, Y.,DeLucia, M.,Mehrens, J.,Gronenborn, A.M.,Ahn, J. (deposition date: 2014-05-21, release date: 2014-10-15, Last modification date: 2023-09-20)
Primary citation	Koharudin, L.M.,Wu, Y.,DeLucia, M.,Mehrens, J.,Gronenborn, A.M.,Ahn, J. Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates. J.Biol.Chem., 289:32617-32627, 2014 Cited by PubMed: 25288794 DOI: 10.1074/jbc.M114.591958 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation