4QG0
Crystal structure of the tetrameric dGTP/dUTP-bound SAMHD1 (RN206) mutant catalytic core
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 550 | 63426.4 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (human) | dNTPase, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1 |
| 2 | E, K, P, T (A, B, C, D) | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (DGT) PubChem (177678918) PubChem (136110594) PubChem (135398599) PubChem (135402022) PubChem (135566345) PubChem (136254580) PubChem (136633653) PubChem (136828797) PubChem (136828798) PubChem (137226754) PubChem (137257907) PubChem (171699498) | |||
| 3 | F, G, L, M, O... (A, B, C, D) | DEOXYURIDINE-5'-TRIPHOSPHATE | non-polymer | 468.1 | 8 | Chemie (DUT) PubChem (44120001) PubChem (44444987) PubChem (46936355) PubChem (57082399) PubChem (59215117) PubChem (689) PubChem (65070) PubChem (92436516) PubChem (92449193) PubChem (445527) PubChem (155898579) | |||
| 4 | H, I, J, N, R... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) PubChem (888) | |||
| 5 | X (D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 113 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 77 | - | expression tag |
| Gly 78 | - | expression tag |
| Ser 79 | - | expression tag |
| Ser 80 | - | expression tag |
| His 81 | - | expression tag |
| His 82 | - | expression tag |
| His 83 | - | expression tag |
| His 84 | - | expression tag |
| His 85 | - | expression tag |
| His 86 | - | expression tag |
| Ser 87 | - | expression tag |
| Ser 88 | - | expression tag |
| Gly 89 | - | expression tag |
| Leu 90 | - | expression tag |
| Val 91 | - | expression tag |
| Pro 92 | - | expression tag |
| Arg 93 | - | expression tag |
| Gly 94 | - | expression tag |
| Ser 95 | - | expression tag |
| His 96 | - | expression tag |
| Met 97 | - | expression tag |
| Ala 98 | - | expression tag |
| Ser 99 | - | expression tag |
| Met 100 | - | expression tag |
| Thr 101 | - | expression tag |
| Gly 102 | - | expression tag |
| Gly 103 | - | expression tag |
| Gln 104 | - | expression tag |
| Gln 105 | - | expression tag |
| Met 106 | - | expression tag |
| Gly 107 | - | expression tag |
| Arg 108 | - | expression tag |
| Asp 109 | - | expression tag |
| Pro 110 | - | expression tag |
| Asn 111 | - | expression tag |
| Ser 112 | - | expression tag |
| Arg 206 | His 206 | engineered mutation |
| Asn 207 | Asp 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 253705.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 6006.1 | |
| All* | Total formula weight | 259711.6 |
