4Q0N
Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
Summary for 4Q0N
Entry DOI | 10.2210/pdb4q0n/pdb |
Related | 4Q0O |
Descriptor | Protein polybromo-1, 1,2-ETHANEDIOL, (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one, ... (4 entities in total) |
Functional Keywords | pb1, polybromo 1 isoform 1, baf180, polybromo-1d, pbrm1, brg1-associated factor 180, bromodomain, chromatin regulator, dna-binding, nucleus, transcription, transcription regulation, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q86U86 |
Total number of polymer chains | 8 |
Total formula weight | 139670.43 |
Authors | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Monteiro, O.,Fedorov, O.,Chaikuad, A.,Yue, W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-04-02, release date: 2014-05-07, Last modification date: 2023-09-20) |
Primary citation | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Monteiro, O.,Fedorov, O.,Chaikuad, A.,Yue, W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand To be Published, |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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