4Q0A

Vitamin D Receptor complex with lithocholic acid

Summary for 4Q0A

Entry DOI	10.2210/pdb4q0a/pdb
Related	2HC4 2HCD
Descriptor	Vitamin D3 receptor A, Nuclear receptor coactivator 2, (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, ... (4 entities in total)
Functional Keywords	alpha-helical sandwich, transcription factor, calcitriol binding, dna binding, nucleus, gene regulation
Biological source	Danio rerio (leopard danio,zebra danio,zebra fish) More
Cellular location	Nucleus: Q9PTN2 Q15596
Total number of polymer chains	2
Total formula weight	36032.31
Authors	Belorusova, A.,Rochel, N. (deposition date: 2014-04-01, release date: 2014-07-02, Last modification date: 2024-02-28)
Primary citation	Belorusova, A.Y.,Eberhardt, J.,Potier, N.,Stote, R.H.,Dejaegere, A.,Rochel, N. Structural insights into the molecular mechanism of vitamin d receptor activation by lithocholic Acid involving a new mode of ligand recognition. J.Med.Chem., 57:4710-4719, 2014 Cited by PubMed: 24818857 DOI: 10.1021/jm5002524 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation