4PZT
Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A
Summary for 4PZT
Entry DOI | 10.2210/pdb4pzt/pdb |
Related | 4PZR 4PZS |
Descriptor | Histone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q09472 |
Total number of polymer chains | 1 |
Total formula weight | 44759.68 |
Authors | Maksimoska, J.,Marmorstein, R. (deposition date: 2014-03-31, release date: 2014-06-11, Last modification date: 2023-09-20) |
Primary citation | Maksimoska, J.,Segura-Pena, D.,Cole, P.A.,Marmorstein, R. Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues. Biochemistry, 53:3415-3422, 2014 Cited by PubMed: 24819397DOI: 10.1021/bi500380f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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