4PQT

Insights into the mechanism of deubiquitination by JAMM deubiquitinases from co-crystal structures of enzyme with substrate and product

Summary for 4PQT

Related2ZNV 4K1R
DescriptorAMSH-like protease sst2, Protein UBBP4, ZINC ION, ... (5 entities in total)
Functional Keywordshelix-beta-helix sandwich, ubiquitin, deubiquitination, zinc metalloprotease, lysine 63-linked polyubiquitin, hydrolase-transcription complex, hydrolase/transcription
Biological sourceSchizosaccharomyces pombe (Fission yeast)
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Cellular locationCytoplasm Q9P371
Total number of polymer chains2
Total molecular weight31177.62
Authors
Shrestha, R.K.,Ronau, J.A.,Das, C. (deposition date: 2014-03-04, release date: 2014-06-18)
Primary citation
Shrestha, R.K.,Ronau, J.A.,Davies, C.W.,Guenette, R.G.,Strieter, E.R.,Paul, L.N.,Das, C.
Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product.
Biochemistry, 53:3199-3217, 2014
PubMed: 24787148 (PDB entries with the same primary citation)
DOI: 10.1021/bi5003162
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.05 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.252301.3%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report