4PP3

Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 6-methyl UAB30 and the coactivator peptide GRIP-1

Summary for 4PP3

Entry DOI	10.2210/pdb4pp3/pdb
Related	3OAP 4K4J 4POH 4POJ 4PP5
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-(6-methyl-3,4-dihydronaphthalen-1(2H)-ylidene)octa-2,4,6-trienoic acid, ... (4 entities in total)
Functional Keywords	ligand binding domain, 6-methyl uab30, rexinoid, cancer, lipid toxicity, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P19793 Q15596
Total number of polymer chains	2
Total formula weight	27785.30
Authors	Xia, G.,Smith, C.D.,Muccio, D.D. (deposition date: 2014-02-26, release date: 2014-06-18, Last modification date: 2023-09-20)
Primary citation	Atigadda, V.R.,Xia, G.,Desphande, A.,Boerma, L.J.,Lobo-Ruppert, S.,Grubbs, C.J.,Smith, C.D.,Brouillette, W.J.,Muccio, D.D. Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J.Med.Chem., 57:5370-5380, 2014 Cited by PubMed: 24801499 DOI: 10.1021/jm5004792 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation