4PP3
Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 6-methyl UAB30 and the coactivator peptide GRIP-1
Summary for 4PP3
Entry DOI | 10.2210/pdb4pp3/pdb |
Related | 3OAP 4K4J 4POH 4POJ 4PP5 |
Descriptor | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-(6-methyl-3,4-dihydronaphthalen-1(2H)-ylidene)octa-2,4,6-trienoic acid, ... (4 entities in total) |
Functional Keywords | ligand binding domain, 6-methyl uab30, rexinoid, cancer, lipid toxicity, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P19793 Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 27785.30 |
Authors | Xia, G.,Smith, C.D.,Muccio, D.D. (deposition date: 2014-02-26, release date: 2014-06-18, Last modification date: 2023-09-20) |
Primary citation | Atigadda, V.R.,Xia, G.,Desphande, A.,Boerma, L.J.,Lobo-Ruppert, S.,Grubbs, C.J.,Smith, C.D.,Brouillette, W.J.,Muccio, D.D. Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J.Med.Chem., 57:5370-5380, 2014 Cited by PubMed: 24801499DOI: 10.1021/jm5004792 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report