4PO6

Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide

Summary for 4PO6

• Entry DOI: 10.2210/pdb4po6/pdb
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, Interferon alpha/beta receptor 1, GLYCEROL, ... (4 entities in total)
• Functional Keywords: ferm, sh2, kinase, receptor, cytokine, intracellular, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Membrane; Single-pass type I membrane protein: P17181
• Total number of polymer chains: 2
• Total formula weight: 67739.16

Authors

Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2014-02-25, release date: 2014-04-02, Last modification date: 2024-04-03)

• Primary citation: Wallweber, H.J.A.,Tam, C.,Franke, Y.,Starovasnik, M.A.,Lupardus, P.J.; Structural basis of IFN receptor recognition by TYK2; Nat.Struct.Mol.Biol., 2014

Experimental method

X-RAY DIFFRACTION (1.99 Å)