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4PO6

Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Non-receptor tyrosine-protein kinase TYK2polymer56763598.61UniProt (P29597)
Pfam (PF18379)
Pfam (PF18377)
Pfam (PF17887)
Pfam (PF21990)
Homo sapiens (human)
2B
(B)
Interferon alpha/beta receptor 1polymer343864.21UniProt (P17181)Homo sapiens (human)IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1
3C, D, E
(A)
GLYCEROLnon-polymer92.13Chemie (GOL)
4F, G
(A, B)
waterwater18.0167Chemie (HOH)
Sequence modifications
A: 23 - 583 (UniProt: P29597)
PDBExternal DatabaseDetails
Gly 21-expression tag
Ser 22-expression tag
Gly 584-expression tag
Ser 585-expression tag
Gly 586-expression tag
Ser 587-expression tag
B: 478 - 507 (UniProt: P17181)
PDBExternal DatabaseDetails
Gly 474-expression tag
Ser 475-expression tag
Gly 476-expression tag
Ser 477-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight67462.9
Non-Polymers*Number of molecules3
Total formula weight276.3
All*Total formula weight67739.2
*Water molecules are not included.

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PDB entries from 2024-11-06

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