4PO6
Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Non-receptor tyrosine-protein kinase TYK2 | polymer | 567 | 63598.6 | 1 | UniProt (P29597) Pfam (PF18379) Pfam (PF18377) Pfam (PF17887) Pfam (PF21990) | Homo sapiens (human) | |
| 2 | B (B) | Interferon alpha/beta receptor 1 | polymer | 34 | 3864.2 | 1 | UniProt (P17181) | Homo sapiens (human) | IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1 |
| 3 | C, D, E (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A: 23 - 583 (UniProt: P29597)
B: 478 - 507 (UniProt: P17181)
| PDB | External Database | Details |
|---|---|---|
| Gly 21 | - | expression tag |
| Ser 22 | - | expression tag |
| Gly 584 | - | expression tag |
| Ser 585 | - | expression tag |
| Gly 586 | - | expression tag |
| Ser 587 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 474 | - | expression tag |
| Ser 475 | - | expression tag |
| Gly 476 | - | expression tag |
| Ser 477 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67462.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 276.3 | |
| All* | Total formula weight | 67739.2 |
